만능세포 유도기술

저자

강*원

게재저널

Tissue Engineering and Regenerative Medicine (http://www.kterms.or.kr/)

키워드

stem cells, iPS, nuclear transplants, reprogramming

개요

Embryonic stem cells are known to renew themselves through cell division and can be induced to develop
into whole different specialized cell types. These characteristics make stem cells worthy of investigation as a source of cells for tissue engineering and cell therapy, but technical and ethical considerations impede the therapeutic application of this technology. Reprogramming of fibroblasts to a pluripotent state can be induced in vitro through ectopic expression of the four transcription factors Oct4, Sox2, c-Myc and Klf4. Many investigators showed that reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells in DNA methylation, gene expression and chromatin state. Advances in reprogramming cellular mechanisms are transforming biomedical research and offer new expectations on development and potential treatment of various diseases. This review focused on recent researches and developments of iPS and is to stimulate the research in an area of tissue engineering.

첨부파일

• 강계원.pdf [497,831 byte]

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